MODEL-AD Explorer



Explore gene expression and pathology data from next generation mouse models of Alzheimer's disease developed by the MODEL-AD consortium.

About MODEL-AD

MODEL-AD comprises two research centers with complementary approaches to generating new mouse models that more faithfully recapitulate features of Alzheimer's disease in humans. Mouse models are phenotyped using standardized neuropathology, 'omics, and behavioral measures.

How to use this site

The MODEL-AD Explorer shares summaries of phenotypic data for available mouse models. Currently available data include:

Pathology data: View neuron and glial cell counts, plaque density and size, and amyloid levels by sex and age.

Gene expression: Explore all up- and down-regulated genes in a selected model or use the “Selected Genes” view to see which models show differential expression of a selected gene.

Correlation with Human Disease: Compare gene expression changes in mouse models with gene expression changes that occur in human disease.

Visit Available Models and Data to learn what data is currently available in the Explorer. New data and analyses will be incorporated as they are available.

Pathology

This explorer shows changes in pathological hallmarks associated with AD. Measurements include measurement of plaques, and counts and density of neurons and glia from immunofluorescent stains.

Please select a phenotype, mouse model, and tissue from the dropdown lists. The matched control is shown next to the model of interest.

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Gene Expression: All genes

These volcano plots show differential expression of genes from RNA sequencing analyses.

Please select a strain and tissue from the dropdown lists.

Significantly upregulated genes in the model compared to control are shown in BLUE, and downregulated genes are shown in RED.

Clicking on a panel of the plot will bring up an interactive plot for that mouse model x sex x age combination.

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Gene Expression: Selected genes

This heatmap shows differential expression of genes from RNA sequencing analyses.

Please select gene(s), model(s), sex(es), and age(s) from the dropdown lists. You can select gene(s) by entering the name(s) or selecting from the list.

Significantly upregulated genes in the model compared to control are shown in BLUE, and downregulated genes are shown in RED. The size of the circle corresponds to the adjusted P value.

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